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Epidemiology of Pulmonary Arterial Hypertension in Latvia

Andris Skride

A. Rudzitis

I. Zakke

A. Erglis

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Conference: 2010 International PHA Conference and Scientific Sessions

Release Date: 06.24.2010

Skride A, Rudzitis A, Zakke I, Erglis A. 
Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, Riga, Latvia

BACKGROUNDThe registry was initiated in the Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, Riga, Latvia since 2008. Data from pulmonary arterial hypertension (PAH) patients from the whole country were prospectively collected. We analyse clinical data and the epidemiological aspects of these data.

METHODSThe registry was opened in January 2008. Patients were screened by transthoracic echocardiography (TTE). The patients with RVSP more than 40 mm/Hg by TTE were sent to right heart catheterization (RHC). PAH was defined as the presence of a mean pulmonary arterial pressure greater than 25 mm Hg at rest and a pulmonary artery wedge pressure less than 15 mm Hg at RHC. Symptomatic adult patients (age ≥ 18 y) with PAH diagnosis (incident cases and prevalent cases) seen between January 2008 and January 2009 were included.

RESULTSA total of 23 patients (mean ± SD age, 51 ± 16 yr; range, 26–76 yr) were entered in the registry. Idiopathic, connective tissue diseases, congenital heart diseases, accounted for 33%, 5%, 62%. of the population, respectively. At the moment of diagnosis, 81% of patients were in New York Heart Association functional class III or IV. Six-minute walk test was 307 ± 107 m. Mean pulmonary artery pressure was 52 ± 20 mm Hg. The low estimates of prevalence and incidence of PAH in Latvia were 10,19 cases/million of adult inhabitants and 3,5 cases/million of adult inhabitants/yr. One-year survival on specific pathogenetic therapy was 88% in the incident cohort.

CONCLUSIONSThis registry shows that in Latvia PAH in most cases is diagnosed in advanced stages of disease. Most of them are patient with uncorrected congenital heart disease. The early screening by echocardiography is crucial in patient groups at risk as the specific pathogenetic therapy is warranted in early stages of PAH.