Conference: 2012 International PHA Conference and Scientific Sessions
Release Date: 01.15.2013
Presentation Type: Scientific Sessions
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease mainly affecting lung distal arteries. Despite many years of investigation, the molecular mechanism of the disease remains elusive. Recent studies have identified pulmonary artery smooth muscle cells and pulmonary endothelial cells proliferation and resistance to programmed cell death as central triggers of vascular lesions seen in PAH. Studies have recently shown that the sustained cell proliferation and resistance to cell death is associated with the activation of molecular pathway sidentical to the one seen in cancer. This cancer hypothesis opens new avenues of investigation and new therapeutic perspectives for treatments of PAH. Preliminary findings in the experimental model along with early clinical findingswill be presented.