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Understanding the Molecular Origin of Pulmonary Hypertension: Role of MicroRNAs

Sebastien Bonnet

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Conference: 2012 International PHA Conference and Scientific Sessions

Release Date: 01.15.2013

Presentation Type: Scientific Sessions

MicroRNA

Learning Objectives: 

  • Describe the mechanism of pulmonary artery remodeling
  • Describe the underlying disorders of miR-204 down regulation in PAH
  • Discuss the putative role of miRNA in PAH treatment

Pulmonary arterial hypertension (PAH) is a vascular remodeling disease mainly affecting lung distal arteries. Despite many years of investigation, the molecular mechanism of the disease remains elusive. Recent studies have identified pulmonary artery smooth muscle cells and pulmonary endothelial cells proliferation and resistance to programmed cell death as central triggers of vascular lesions seen in PAH. Studies have recently shown that the sustained cell proliferation and resistance to cell death is associated with the activation of molecular pathway sidentical to the one seen in cancer. This cancer hypothesis opens new avenues of investigation and new therapeutic perspectives for treatments of PAH. Preliminary findings in the experimental model along with early clinical findingswill be presented.