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Inflammation in HIV-related Pulmonary Hypertension: Cause or Effect? Lessons from Animal Models

Sonia C. Flores


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Conference: 2010 International PHA Conference and Scientific Sessions

Release Date: 06.22.2010

Presentation Type: Scientific Sessions

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This lecture will cover general background information about the prevalence and pathogenesis of HIV-related pulmonary hypertension, including known associated biomarkers and molecular mechanisms. The contribution of the HIV Nef (negative factor) protein as an adaptor and downstream activator of intracellular signaling pathways that influence inflammatory processes will be discussed. Finally, mutations in Nef alleles that may influence pulmonary vascular cell physiology will be placed in the context of structural-functional alterations that may contribute to vascular remodeling.