Conference: 2010 International PHA Conference and Scientific Sessions
Release Date: 06.22.2010
Presentation Type: Scientific Sessions
This lecture will cover general background information about the prevalence and pathogenesis of HIV-related pulmonary hypertension, including known associated biomarkers and molecular mechanisms. The contribution of the HIV Nef (negative factor) protein as an adaptor and downstream activator of intracellular signaling pathways that influence inflammatory processes will be discussed. Finally, mutations in Nef alleles that may influence pulmonary vascular cell physiology will be placed in the context of structural-functional alterations that may contribute to vascular remodeling.