May 18, 2018
Sheraton Hotel, Palo Alto, California 625 El Camino Real Palo Alto, CA 94301 United States
With the recent advances in biology such as single cell transcriptomics and spacial proteomics, lineage tracing and the use of induced pluripotent stem cells to model diseases in a dish, we are equipped with novel tools to better study disease pathogenesis. This exciting new field of precision biology will transform the way we will understand disease pathogenesis, identify novel treatment targets and develop precise and effective therapies. Precision medicine is an approach to disease treatment that takes into account individual variability in genes, environment, and lifestyle to identify clinical phenotypes that would benefit from targeted and highly effective therapies. The importance of precision medicine to the future of US health care had been stressed buy President Obama in his Precision Medicine Initiative, which aims to provide healthcare providers with a way to integrate seemingly disparate data points (e.g. genetics, proteomics, epigenetics, metabolomics, medical record data, etc.) into a platform that can improve clinical outcomes and quality of health care. Given the growing advances in our understanding of the pathobiology and management of pulmonary arterial hypertension (PAH), the time is ripe to discuss how state- of-the-art sequencing strategies tailored to capture single cell genotypes along with growing applications for the use of integrated 'Omics technologies and machine based learning could help facilitate the translation of scientific discoveries into clinical tools (e.g. biomarkers, prediction algorithms, clinical trial design, drug discovery, etc.) that can help improve our capacity to properly diagnose and design the optimal treatment strategy of PAH patients.
More Information: http://med.stanford.edu/phsymposium.html
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