TGF-beta Receptors in Pulmonary Arterial Hypertension: The HHT Connection Substantial progress in delineating the molecular and genetic basis of pulmonary arterial hypertension has placed the TGFbeta cell-signaling pathway as the centerpiece of contemporary thinking about the pathogenesis of this disorder.
The Serotonin Pathway in Pulmonary Hypertension The effects of serotonin (5-hydroxytryptamine, 5-HT) on the pulmonary circulation have been investigated because of the reported increased risk of idiopathic pulmonary arterial hypertension (IPH) in patients who used appetite suppressants that interact with 5-HT.
The Future of Genetics in Pulmonary Arterial Hypertension Research into the genetic basis of pulmonary arterial hypertension is going forward with increasing intensity. It appears that mutations in bone morphogenetic protein receptor type II (BMPR2) and activin receptor-like kinase-1 (ALK1) genes will be the most common genetic risk factors for the development of pulmonary arterial hypertension.
